Treatment-resistant depression describes a condition in which people with major depressive disorder do not see improvement in their depression symptoms from at least two different antidepressants for a period longer than 8 weeks at a dose which is greater than the lowest recommended dose.
2. What causes treatment-resistant depression?
There is no single cause for treatment-resistant depression. A mix of factors could be involved, including:
The wrong diagnosis
Certain kinds of depression that don’t respond as well to antidepressant drugs
The antidepressant drugs being taken may simply not be effective enough
3. What are the signs and symptoms of treatment-resistant depression?
Symptoms of clinical depression continue
Lack of response to multiple antidepressant treatments
4. What are the signs and symptoms of clinical depression?
Signs and symptoms may include:
Feelings of sadness, emptiness or uselessness
Loss of interest in regular activities
Feeling slowed down in your thinking and movements
Not wanting to be alive
Tiredness or lack of energy
Loss of appetite and weight
Trouble focusing, decision-making, and remembering
Unexplained physical pain such as headaches
Symptoms are typically severe enough to impact daily activities and relationships.
5. What is the purpose of this study?
This study is designed to assess the effect that the study drug has on patients with treatment-resistant depression.